I agree that the gem mentioned might not be suitable, but Ruby could still have a part to play, especially as it allows direct use of native libraries, or just managing processes running on the OS.
Someone doing this should probably write the fast-spinning cogs in C, but it might be worth using Ruby to manage threads, processes, data segments, etc - indeed, maybe prototype the C code there first too. You'd gain an awful lot of convenience for very little overhead.
Check out the Amatch ruby gem ... it can compute the hamming distance ... might be easy to automate with ruby ...
http://amatch.rubyforge.org/doc/index.html