Either I've grown up a whole lot in the last two years (possible), or the influx of new Redditors from ... well, everywhere ... pretty much killed the appeal the place had for me. It lost its exclusive feel, and now a 'Redditor' is just any random American college kid.
It's HN that I check when I wake up or when I'm bored now - comments here are likely to be things I want to read.
For me its the mix of juvenile college kids and (as Steve Yegge pointed out) the Simpson's "Comic Book Guy" type meta-commenters that drive me nuts. 4/5 times I hit the "load more comments" link I feel a deep sense of regret. =P