Hacker Newsnew | past | comments | ask | show | jobs | submitlogin

I cannot speak for Dante, but I have used Veritas for whole genome sequencing and only have good things to say about them.


There may be nice things to say about Veritas, but they charge an extra $99 for VCF files, and the actual raw data (FASTQ/BAM) is not available at any price (to you; Veritas has it). This is after you've paid $1,000 for sequencing.


What does VCF lack vs FASTQ/BAM?


VCF only contains variant information; FASTQ and BAM contain the “raw” sequencing information (in reality that data is already heavily processed but it’s the starting point for all usual analysis). Depending on how you do the analysis, the variant data will be slightly different. There are some current baselines (so-called “best practice” workflows) for performing the analysis but many of the details are variable, and subject to much current research.

To be fair, for most things the VCF is completely sufficient (and in fact most people won’t care even about that). It just feels cooler to be in control of the raw data (and personally if I end up using a sequencing service, I would want to perform my analysis; but this is obviously irrelevant for 99.99% of users).


Did you learn anything useful? (I'm not asking the specifics of what you learnt, but say... Is it helpful to know disease related info? Ancestry? Etc)


I didn't dive into the data. I provided it to researchers, along with my medical records, as part of Harvard's Personal Genome Project.




Guidelines | FAQ | Lists | API | Security | Legal | Apply to YC | Contact

Search: