It was never definitively proven but poorly designed software was considered to be at the heart of a helicopter crash that killed 25 people including almost all of the UK's top North Ireland intelligence experts: http://en.wikipedia.org/wiki/1994_Scotland_RAF_Chinook_crash...
Software controls everything from nuclear power stations to missles to dams to radiation therapy machines (where, again, software killed 3 people - http://en.wikipedia.org/wiki/Therac-25)
Proper software engineering is increasingly more important and, I'd posit, likely to become even more important than civil engineering for public safety as time goes on.
I'll agree mission critical software exists. I however imagine there are far more engineering projects across the planets whose failure result in mass casualties than software. There is a reason actual engineers are legally liable for their work.
Real engineering projects every day use software—I don't think you can realistically draw a line between the two, even if there are different auditing standards.